Individualize. Maintain supine position; monitor BP. Repeated IV inj: 20mg over 2 minutes, may give additional 40mg or 80mg at 10 minute intervals up to max total dose of 300mg or until desired supine BP. Slow continuous infusion: 2mg/min (see literature in our Tutorials).
Bronchial asthma. Overt cardiac failure. 2nd– or 3rd– degree AV block. Cardiogenic shock. Severe bradycardia. Other conditions associated with severe and prolonged hypotension. History of obstructive airway disease (eg, asthma).
Ischemic heart disease or failure. Monitor hepatic function: discontinue at first sign of liver injury. If signs of cardiac failure, treat with digitalis or diuretic, discontinue if failure continues. COPD. Pheochromocytoma. Diabetes. Surgery. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Noncardioselective beta-blocker/alpha-1 blocker.
Caution with verapamil. Potentiates hypotension with nitroglycerin. May blunt effects of epinephrine, β-agonist bronchodilators. Avoid alkaline drugs (eg, furosemide) administration in same infusion line. Adjust antidiabetic medication. Potentiated by cimetidine and halothane. Tremor with tricyclic antidepressants. May cause false positive urine test for amphetamine.
Symptomatic postural hypotension, GI upset, dizziness, increased BUN and serum creatinine, paresthesias, sweating, somnolence, flushing, ventricular arrhythmia, vertigo, pruritus.
Formerly known under the brand names Normodyne, Trandate.